Maxa JL, Melton LB, Ogu CC, Sills MN, Limanni A "Rhabdomyolysis after concomitant use of cyclosporine, simvastatin, gemfibrozil, and itraconazole." South Med J 94 (2001): 1023-6, 16. Arch Intern Med 152 (1992): 1093, 55. Stomach Cramps Zetia, atorvastatin, Jardiance, simvastatin, Brilinta, fenofibrate, Lopid, Xarelto, rosuvastatin, Lipitor. ChoquetKastylevsky G, Kanitakis J, Dumas V, Descotes J, Faure M, Claudy A "Eosinophilic fasciitis and simvastatin." Constipation 5. Nakad A, Bataille L, Hamoir V, Sempoux C, Horsmans Y "Atorvastatin-induced acute hepatitis with absence of cross-toxicity with simvastatin." All rights reserved. Muldoon MF, Ryan CM, Sereika SM, Flory JD, Manuck SB "Randomized trial of the effects of simvastatin on cognitive functioning in hypercholesterolemic adults." Katznelson S "Effect of HMG-CoA reductase inhibitors on chronic allograft rejection." The pain can range in severity from a mild nuisance to severe and debilitating. Hypersensitivity reactions; Other side effects include: memory loss, forgetfulness, amnesia, confusion, and; memory impairment. Head Pain 9. "Product Information. Nausea 13. J Thorac Cardiovasc Surg 116 (1998): 654-5, 32. For the Consumer. Lancet 353 (1999): 1763-4, 38. Muscle Pain 4. Simvastatin oral tablet doesn’t drowsiness, but it can cause other side effects. This pain can include soreness and/or weakness in the muscles. It's thought that simvastatin (Zocor) may be more likely to cause muscle pain as a side effect than other statins when it's taken at high doses. Duits N, Bos FM "Depressive symptoms and cholesterol-lowering drugs." Morales K, Wittink M, Datto C, et al. You can also get an upset tummy and very seldom, headaches dizziness, tiredness and sleeplessness can occur as a result of simvastatin. JAMA 292 (2004): 2585-90, 13. With therapy discontinuation or interruption, transaminase levels generally returned to pretreatment levels. See below for a comprehensive list of adverse effects. Plosker GL, Mctavish D "Simvastatin - a reappraisal of its pharmacology and therapeutic efficacy in hypercholesterolaemia." DICP 25 (1991): 257-64, 39. Pharmacotherapy 26 (2006): 414-22, 42. Side … See below for a comprehensive list of adverse effects. Mukhtar RY, Reckless JP "Statin-induced myositis: a commonly encountered or rare side effect?" I haven't used simvastatin personally, but I can tell you a bit about the side effects of the drug. How Long Does Coronavirus Live On Surfaces? Meier CR, Schlienger RG, Kraenzlin ME, Schlegel B, Jick H "HMG-CoA reductase inhibitors and the risk of fractures." Finsterer J, Zuntner G "Rhabdomyolysis from Simvastatin triggered by infection and muscle exertion." Walker JF "Simvastatin: the clinical profile." Bronchitis 3. The most common ones are muscle weakness, muscle cramps and muscle aches. Drugs 50 (1995): 334-63, 5. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. More frequently reported side effects include: eczema and increased creatine phosphokinase in blood specimen. Arora R, Liebo M, Maldonado F "Statin-induced myopathy: the two faces of Janus." Change your dose. The more common side effects that can occur with simvastatin include: Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. Weise WJ, Possidente CJ "Fatal rhabdomyolysis associated with simvastatin in a renal transplant patient." Some side effects may not be reported. J Am Geriatr Soc 54 (2006): 70-6, 47. Pedersen TR, Kjekshus J, Berg K, Haghfelt T, Faergeman O, Thorgeirsson G, Pyorala K, Miettinen T, Wilhelmsen L, Olsson AG, Wedel "Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)." Rhabdomyolysis can cause severe muscle pain, liver damage, kidney failure and death. If experienced, these tend to have a Severe expression, If experienced, these tend to have a Less Severe expression. [Ref], Persistent elevations in transaminases of up to 3 times the upper limit of normal (3xULN) have been reported in 1% of patients. Johnson JL, Loomis IB "A case of simvastatin-associated pancreatitis and review of statin-associated pancreatitis." J Neurol Neurosurg Psychiatry 58 (1995): 625-8, 46. Padala KP, Padala PR, Potter JF "Simvastatin-induced decline in cognition." What are the more serious side effects of Zocor? Simvastatin oral tablet doesn’t drowsiness, but it can cause other side effects. Dermatology 186 (1993): 272, 54. Galatti L, Polimeni G, Salvo F, Romani M, Sessa A, Spina E "Short-term memory loss associated with rosuvastatin." Bilheimer DW "Long-term clinical tolerance of lovastatin and simvastatin." Check with your doctor immediately if any of the following side effects occur while taking rosuvastatin: More common While statins are well tolerated by many individuals, certain patients are at an increased risk of developing side effects. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. The Principal Investigators." Peces R, Pobes A "Rhabdomyolysis associated with concurrent use of simvastatin and diltiazem." Chariot P, Abadia R, Agnus D, Danan C, Charpentier C, Gherardi RK "Simvastatin-induced rhabdomyolysis followed by a MELAS syndrome." WebMD does not provide medical advice, diagnosis or treatment. Lowering your dose may reduce some of your side effects, but it may also reduce some of the cholesterol-lowering benefits your medication has. Cerner Multum, Inc. "UK Summary of Product Characteristics." Am J Med 110 (2001): 716-23, 59. Lancet 344 (1994): 1383-9, 52. Muscle pain is one of the most common side effects reported by people who take a statin. 40. Applies to simvastatin: oral suspension, oral tablet. O 0, 23. J Intern Med 240 (1996): 403-4, 18. Is Repatha (evolocumab) effective without a statin? "Simvastatin causes changes in affective processes in elderly volunteers." Clin Cardiol 16 (1993): 317-22, 9. Pharmacotherapy 25 (2005): 228-43, 28. Federman DG, Hussain F, Walters AB "Fatal rhabdomyolysis caused by lipid-lowering therapy." Orsi A, Sherman O, Woldeselassie "Simvastatin-associated memory loss." Are Statin Side Effects 'All in Your Head'? Merck & Co, Inc, West Point, PA. 20. Br J Rheumatol 33 (1994): 199, 8. Medicine 77 (1998): 378-83, 56. Sundram F, Roberts P, Kennedy B, Pavord S "Thrombotic thrombocytopenic purpura associated with statin treatment." South Med J 98 (2005): 827-9, 35. Lancet 341 (1993): 114. Simons LA "Simvastatin in severe primary hypercholesterolemia: efficacy, safety, and tolerability in 595 patients over 18 weeks. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Pharmacotherapy 26 (2006): 1190-2, 44. Serious Side Effects of Statins Statins are linked to a few rare but potentially serious side effects, including: Myositis, which is inflammation of the muscles.
what are the most common side effects of simvastatin