Three datasets, a … The commonest side effects … We know this from the clinical studies that have been carried out. In randomized clinical trials (RCTs) proprotein convertase subtilisin/kexin 9 (PCSK9) inhibitors showed a favorable safety profile, however, "real-world" data on adverse events (AEs) is scarce. Repatha Syringe 140 Mg/Ml Subcutaneous Antihyperlipidemic - PCSK9 Inhibitors Side Effects by Likelihood and Severity COMMON side effects. All medicines can have side effects but the good news is that PCSK9 inhibitors appear to be well tolerated by most people. Overall, patients treated with PCSK9 inhibitors had higher rates of nonspecific side effects, such as arthralgia, headache, limb pain and … 7. Side Effects With PCSK9 Inhibitors In clinical studies with PCSK9 inhibitors, a majority of patients had at least some side effects—mainly skin reactions at the injection site, but adverse reactions also included muscle pain (similar to the muscle side effects … If experienced, these tend to have a Less Severe … One side effect has generated particular concern.