Marotta, R. B. and Floch, M. H. Diet and nutrition in ulcer disease. Novel pepper extract for enhanced P-glycoprotein inhibition. Vet.Parasitol. Bajad, S., Bedi, K. L., Singla, A. K., and Johri, R. K. Antidiarrhoeal activity of piperine in mice. Cancer Lett 1993;72:5-9. Antimicrobial agents from plants: antibacterial activity of plant volatile oils. Title 21. 2018;32(9):1812-1817. 2018;32(9):1848-1852. 2009;61(9):1179-1186. Subehan, Usia, T., Kadota, S., and Tezuka, Y. Mechanism-based inhibition of human liver microsomal cytochrome P450 2D6 (CYP2D6) by alkamides of Piper nigrum. View abstract. Piper nigrum and piperine: an update. Selvendiran, K., Banu, S. M., and Sakthisekaran, D. Protective effect of piperine on benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice. Bano G, Amla V, Raina RK, et al. View abstract. A., Romeiro, A., Mendonca-Previato, L., Previato, J. O., de Lima, M. E., de Carvalho, T. M., and Heise, N. The toxic effects of piperine against Trypanosoma cruzi: ultrastructural alterations and reversible blockage of cytokinesis in epimastigote forms. In vitro and in vivo evaluation of the effects of piperine on P-gp function and expression. What factors influenced or will influence your purchase? Talk with your healthcare provider before using this product if you are taking lithium. Velpandian T, Jasuja R, Bhardwaj RK, et al. J Oleo.Sci 2008;57(3):171-179. View abstract. View abstract. Phytomedicine. 2001;66(2a):473-478. Ren T, Yang M, Xiao M, Zhu J, Xie W, Zuo Z. Time-dependent inhibition of carbamazepine metabolism by piperine in anti-epileptic treatment. Black and white pepper might decrease how quickly the liver breaks down some medications. 10-15-2009;17(20):7313-7323. Br J Pharmacol 2005;144(6):781-790. Acute effects of a caffeine-containing supplement on bench press and leg extension strength and time to exhaustion during cycle ergometry. Indian J.Gastroenterol. Early research in men who are not trained athletes shows that taking a supplement containing black pepper and other ingredients before exercise does not improve performance. Yakushigaku.Zasshi 1995;30(1):46-53. Effect of red pepper and black pepper on the stomach. Electronic Code of Federal Regulations. Myers, B. M., Smith, J. L., and Graham, D. Y. Fatigue. Cordell B, Buckle J. Lawless, H. and Stevens, D. A. Park, I. K., Lee, S. G., Shin, S. C., Park, J. D., and Ahn, Y. J. Larvicidal activity of isobutylamides identified in Piper nigrum fruits against three mosquito species. Panda, S. and Kar, A. Piperine lowers the serum concentrations of thyroid hormones, glucose and hepatic 5'D activity in adult male mice. View abstract. Piperine is a major alkaloid found in black pepper (piper nigrum), and the alkaloid is used as an herbal product for its purported anti-inflammatory, antioxidant, and antitumor properties. View abstract. Early research shows that applying black pepper oil near the right side of the nose in order to inhale the scent improves stability in older people when their eyes are closed. Exp.Toxicol.Pathol. Phytother Res. Drug Chem.Toxicol. Zutshi, R. K., Singh, R., Zutshi, U., Johri, R. K., and Atal, C. K. Influence of piperine on rifampicin blood levels in patients of pulmonary tuberculosis. View Abstract. 2008;21(3):151-157. View abstract. Indian J Exp.Biol. Wrba, H., el Mofty, M. M., Schwaireb, M. H., and Dutter, A. Carcinogenicity testing of some constituents of black pepper (Piper nigrum). Am J Dis Child 1988;142:633-6. Biochem.Biophys.Res.Commun. Part 182 -- Substances Generally Recognized As Safe. Black and white pepper might increase how much propranolol (Inderal) the body absorbs. Lithium interacts with BLACK PEPPER AND WHITE PEPPER. It might also decrease how quickly the body breaks down and gets rid of carbamazepine. Faas, L., Venkatasamy, R., Hider, R. C., Young, A. R., and Soumyanath, A. Before taking black or white pepper, talk to your healthcare provider if you are taking any medications that are changed by the liver. 2007;8(6):383-391. Taking black and white pepper along with phenytoin (Dilantin) might increase the effects and side effects of phenytoin (Dilantin). Parasitol.Res. View abstract. Early research in men who smoke shows that puffing on a vapor device containing black pepper oil over 3 hours may reduce cigarette cravings and anxiety. View abstract. Keep in mind that natural products are not always necessarily safe and dosages can be important. View abstract. View abstract. View abstract. Trouble swallowing. View abstract. Br.J Dermatol. This might cause more side effects from some medications. Early research in these children shows that applying black pepper oil to the nostrils or nasal cavity for one minute before meals can improve swallowing and the amount of food they can eat.